Within a couple hours I was able to get the Appcelerator IDE setup, attach the Android API, and deploy a ‘Hello World’ application to a Kindle Fire. I suggest using a native device to test applications since the Android emulator is uber slow. The most recent release of Appcelerator also offers remote application debugging.
I’m in the process of using REST APIs provided by ShelfReliancePro to create a mobile app for that web application. So far it has gone pretty well and was able to load data from the API into the Android App.